top of page

Questions and Answers

Public·22 members
Joseph Howard
Joseph Howard

Michael Jackson Blood On The Dan [UPDATED]



NIGHT & DAY (TNT)(written by Todd Robinson & Joel Surnow; directed by Milan Cheylov; TRT: 37:00) What is it? A drama about an ATF agent who faces struggles both at home and at work.Who was behind it?: "24" co-creator Joel Surnow penned the hour alongside screenwriter Todd Robinson ("Lonely Hearts"). Milan Cheylov ("24") directed.The plot in a nutshell: "Night. Day. Two worlds. Two stories. One man. My husband," explains Elizabeth Hollister ("ER's" Sherry Stringfield). The man in question: Dan Hollister ("Prison Break's" William Fichtner), head of field operations for the Special Threat Intervention unit, a joint task force between the ATF, DEA, FBI and local law enforcement. He's out to catch bad guys like Antone Bello (Antone Pagan), an arms dealer looking to bring a shipment of Stinger missiles into the country. Aiding him in his quest are his veteran lieutenants, Bobby Kohl ("Lights Out's" Holt McCallany) and Dave Preston (Michael Beach). Essentially autonomous because they get things done, Dan is surprised to hear from his boss Bill Greer (Conor O'Farrell) the higher ups want some fresh blood - Pollard (Riley Smith), Talbot (Dondre Whitfield) and Hicks (Charles Michael Davis) - to accompany them on their latest mission. It's a move that results in Dave putting in his transfer papers, as he can't believe the brass is screwing around when such a big fish is in play. The newbies nevertheless carry their weight but at the cost of Hicks taking a few rounds in the chest and their target nearly dying before giving up the location of the missile exchange: just across the Fortuna River in Mexico. It's a bust that requires the STI to go off-book as they don't have jurisdiction there. Thankfully everyone is more than willing to follow Dan's lead as Bello is ultimately arrested and the Stingers are intercepted. Mission accomplished, Dan heads home for a different type of battle - his family. There we find youngest Jackson (Asher Axe) is more interested in video games than doing his chores and middle child Alison (Kaili Thorne) has developed a habit of dressing inappropriately and stealing the family car. Holding it all together then is Liz who also makes sure Dan leaves work at work, even if he comes home in a bloody shirt. She's also got some news of her own: she might be pregnant with their fourth child.Tonight's task however is to survive dinner with their eldest Sarah (Jessy Schram), her boyfriend Eric (Ian Nelson) and his college professor father Jay (Xander Berkeley) and girlfriend Skye (Wendy Glenn). And despite warnings from Eric of a difficult night ahead, things go off swimmingly... that is until Jay begins badgering Eric about his life decisions (go to med school instead of teach, what a waste!) and Dan has the gall to defend him. Said dust up quickly escalates as Jay provokes Dan about his Medal of Valor he received after the Waco incident. The breaking point comes when Dan slams his sidearm on the table and asks Jay to leave, shocking Liz and Sarah but impressing Eric that someone finally stood up to his bully father. And really that's about it until the closing moments when Dan and Liz learn the pregnancy was a false alarm followed by Dan getting a call informing him Hicks (the newbie who got shot) died from complications due to a blood clot. What works: It's a very weird show...What doesn't: ...and I don't mean that in a good way. The best way to describe "Night & Day" is pick just about any procedural cop show then imagine if one of those characters went home after the second act and a family drama - that makes nary a reference to the previous two acts - took over for the second half of the show. The transition, which includes title cards for "Night" and "Day," is literally that jarring. Not helping matters is that neither part is particularly engaging: "Night" is fairly lightweight cop stuff (no detective work, just straight takedowns) while "Day" is melodramatic homefront foibles (Alison throws a fit that dad doesn't understand!). Even worse, Fichtner never quite sells Dan's supposed dilemma: he's a team player at work who's routinely asked to do more with less, the frustrations of which come out at home during the most inopportune times - like during dinner your daughter's potential in-laws. Theoretically there's a show in that premise however its connections are so tenuous (I'm honestly just taking stabs at the dark here) and the events so are ham-fisted (Dan gets baited by a college freshman-esque argument over Waco, really?) that "Night" and "Day" come across as two unrelated elements juxtaposed together...The bottom line: ...instead of a cohesive show.




Michael Jackson Blood On The Dan



Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.


N2 - Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.


AB - Elevated blood pressure is a major risk factor for cardiovascular disease and has a substantial genetic contribution. Genetic variation influencing blood pressure has the potential to identify new pharmacological targets for the treatment of hypertension. To discover additional novel blood pressure loci, we used 1000 Genomes Project-based imputation in 150 134 European ancestry individuals and sought significant evidence for independent replication in a further 228 245 individuals. We report 6 new signals of association in or near HSPB7, TNXB, LRP12, LOC283335, SEPT9, and AKT2, and provide new replication evidence for a further 2 signals in EBF2 and NFKBIA Combining large whole-blood gene expression resources totaling 12 607 individuals, we investigated all novel and previously reported signals and identified 48 genes with evidence for involvement in blood pressure regulation that are significant in multiple resources. Three novel kidney-specific signals were also detected. These robustly implicated genes may provide new leads for therapeutic innovation.


The number of people who are 80-years-old and older is on the rise, and will account for nearly 10 percent of the whole U.S. population by 2050. Since the lifetime chance for developing high blood pressure is at least 70 percent by age 80, more and more people will be at risk for the health problems that high blood pressure can cause.


Given this knowledge gap, a team of researchers focused on this group of older adults within a large randomized trial called the Systolic Blood Pressure Intervention Trial (SPRINT). They published their findings in the Journal of the American Geriatrics Society. In their analysis of SPRINT data, the researchers focused on people aged 80 and older, who had reported heart disease events (such as heart attacks or strokes), changes in kidney function, cognitive impairment, quality of life, or death. The researchers also explored whether impairments in cognitive or physical function had any effect on intensive blood pressure control.


The analysis included 1,167 participants. Most were around 84 years old, and about 3 percent were 90 or older. Their baseline systolic blood pressure was around 142 mmHg. Most of the participants had at least three chronic health conditions. More than half were taking at least five medications and about 27 percent had a history of heart disease.


The people who received treatment to lower their blood pressure to less than 120 mmHg experienced a lower risk for heart disease events, as well as less risk for mild cognitive impairment and death from all causes. However, people in this group also experienced an increased risk of small, but meaningful, declines in kidney function as well as hospitalizations for short term kidney damage (from which most people recovered). Attempting to lower systolic blood pressure to less than 120 mmHg did not increase the risk for injury-causing falls. This is important, since falls raise the risk for death in older adults and low blood pressure can result in falls.


The researchers also reported that people with better cognitive function (remembering, thinking, and making decisions) at the beginning of the study benefited the most from intensive blood pressure control. They also experienced less heart disease and fewer deaths. This same benefit was not seen in participants who had poorer cognitive function at the beginning of the study. However, there was not strong evidence of intensive blood pressure control having a harmful impact on death rates or developing heart disease for those with poorer cognitive function.


About

Welcome to the group! You can connect with other members, ge...
bottom of page